GLP-2 & Sustainable Fat Loss: A Skorch Case Study
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​​​​DEXA Scans: Full Body Composition Analysis
GLP-2 (Glucagon-Like Peptide-2) is a gut-derived hormone primarily known for its role in intestinal health, nutrient absorption, and metabolic efficiency. Traditionally studied for its ability to strengthen the intestinal lining and improve nutrient uptake, GLP-2 also appears to influence appetite signaling and metabolic regulation. By improving how the body absorbs and utilizes nutrients, GLP-2 can support fat loss while helping preserve lean tissue—when paired with proper nutrition. This makes it fundamentally different from weight-loss approaches that rely solely on calorie restriction or appetite suppression.
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In a small internal Skorch trial of six participants using GLP-2 (referred to in the program as “Tirzepatide GLP-2”), results were notably encouraging. Four participants lost between 8 and 12 pounds, while two regained weight after failing to follow the prescribed dietary guidelines. Importantly, all four successful participants consumed their full metabolic calorie targets during the trial—demonstrating that weight loss occurred without starvation. All six participants reported a noticeable reduction in appetite and a quieting of food “noise,” which paradoxically made it harder for some to meet their metabolic nutrition goals, reinforcing the importance of structured oversight.
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A critical takeaway from this trial was the role of lean muscle mass. The two participants who regained weight were also the ones who did not adhere to nutrition protocols—leading to muscle loss and predictable rebound weight gain. As Skorch emphasizes, losing muscle during weight loss virtually guarantees future weight regain. Moving forward, Skorch will offer GLP-2 as an optional tool within its programs, but only under strict supervision, including mandatory DEXA scans at baseline and again at four weeks to confirm muscle preservation. The objective is not just weight loss, but sustainable metabolic health—where fat is lost, muscle is protected, and results last long after the program ends.
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